Modeling Gene-Environment Interactions With Quasi-Natural Experiments
نویسندگان
چکیده
منابع مشابه
Modeling Gene-Environment Interactions With Quasi-Natural Experiments.
This overview develops new empirical models that can effectively document Gene × Environment (G×E) interactions in observational data. Current G×E studies are often unable to support causal inference because they use endogenous measures of the environment or fail to adequately address the nonrandom distribution of genes across environments, confounding estimates. Comprehensive measures of genet...
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OBJECTIVES We aimed at extending the Natural and Orthogonal Interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of the NOIA statistical models using simulated data and lung cancer data. METHODS The NOIA statisti...
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The concept of storing radioactive waste in geological formations calls for large quantities of concrete that will be in contact with the clay material of the engineered barriers as well as with the geological formation. France, Switzerland and Belgium are studying the option of clayey geological formations. The clay and cement media have very contrasted chemistries that will interact and lead ...
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One of the limitations of interdisciplinarity is the misunderstanding regarding specific words and concepts from one discipline to the other ( ). One way to circumvent this aspect is to incorporate the vocabulary of other disciplines, when it corresponds to the appropriate 1 concept. Gene environment interaction is a popular topic, for which there has been to date, more reviews than established...
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doi: 10.1289/ehp.10217 In their otherwise informative and concise review of the current state of evidence concerning risk factors for acute childhood leukemia, Belson et al. (2007) did not correctly address nonionizing radiation and, in particular, power frequency magnetic fields as a possible risk factor for childhood leukemia. This failure may be due to a widespread misconception about the ev...
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ژورنال
عنوان ژورنال: Journal of Personality
سال: 2015
ISSN: 0022-3506
DOI: 10.1111/jopy.12227